Pharmacometrician

Job Title: Pharmacometrics / PBPK Leader

Location: Remote Based

Job Type: Full time

Role overview:

As Pharmacometrics / PBPK Lead, you will be responsible for leading the development and application of physiologically based pharmacokinetic (PBPK) models to support biologics programs across discovery, preclinical, and clinical stages. You'll work cross-functionally with DMPK, clinical pharmacology, regulatory, and translational sciences teams to influence strategic decisions and optimize drug development.

Key Responsibilities

• Lead PBPK modeling strategies for monoclonal antibodies, ADCs, fusion proteins, and other biologics.
• Develop and validate mechanistic models to support dose selection, trial design, and regulatory submissions.
• Partner with discovery and development teams to influence candidate selection and first-in-human dosing strategies.
• Interpret and communicate model outcomes to cross-functional stakeholders and senior leadership.
• Represent PBPK strategy in regulatory interactions and author relevant sections of INDs, CTAs, and BLAs.
• Mentor junior scientists and contribute to best practices in model-informed drug development (MIDD).

Qualifications

• PhD in Pharmacokinetics, Pharmaceutical Sciences, Biomedical Engineering, or related field.
• 5+ years of industry experience in PBPK modeling, with a strong focus on biologics.
• Proficiency in software such as Simcyp, PK-Sim, GastroPlus, MATLAB, or similar tools.
• Deep understanding of ADME and pharmacokinetics of large molecules.
• Experience contributing to regulatory filings and interacting with health authorities.
• Strong communication and presentation skills.

About Planet Pharma:

Planet Pharma is an American parented Employment Business/Agency that provides global staffing services with its head-quarters in Chicago and our EMEA regional office located in Central London. We have invested significantly in creating a robust international platform that enables us to work compliantly in 30+ countries with a current network of 2500+ active contractors globally as well as a very strong permanent / direct hire recruitment offering.

Our specialist knowledge and close relationships with our clients and the wider industry really makes us unique in our field. Just recently we were recognised by FORBES as the 17th best professional staffing firm, and have won multiple awards from industry accredited bodies for our commitment to excellence and service delivery. We have extensive functional expertise including: Regulatory Affairs, Pharmacovigilance, QA, QC, Submissions experts, Clinical development, Quality, Biostatistics, and Medical Affairs / Writing.

We are an equal opportunities Recruitment Business and Agency. We welcome applications from all suitably qualified candidates regardless of their race, sex, disability, religion/belief, sexual orientation or age.